Antihypertensive Effects of a Central Arteriovenous Anastomosis Are Mediated Through Profound Reduction in Systemic Vascular Resistance.
نویسندگان
چکیده
Device-based therapies increase therapeutic options for the treatment of hypertension for patients who fail polypharmacy because of adverse reactions or choice. Here we report the physiology related to a device, which uniquely addresses the structural pathogenesis of hypertension. Creation of a fixed-size central arteriovenous anastomosis mechanically causes an immediate and significant reduction of blood pressure (BP). We present the first detailed hemodynamic findings before and after implantation of the ROX Coupler.
منابع مشابه
Evaluation of vascular effects of aqueous Crocus sativus petals’ extract in the hypertensive rats
Background and Aim: Crocus sativus (C. sativus) petals attenuates smooth muscle tension and blood pressure in control animals. However the antihypertensive effect and its mechanisms haven’t been recognized. This study investigates the antihypertensive effects of C. sativus petals’ aqueous extract in hypertensive rats and also responses of the rat isolated perfused mesenteric bed. Materials and...
متن کاملPulmonary hypertension and erythropoietin.
Numerous uremic patients on hemodialysis have pulmonary hypertension attributable to the presence of arteriovenous fistulas, vascular calcification, and endothelial dysfunction due to alterations in the balance between vasoconstrictive and vasodilatory substances. For these reasons, the effects of recombinant human erythropoietin, a drug widely used in patients on dialysis, on the pulmonary cir...
متن کاملArteriovenous fistula in the neonate.
Arteriovenous fistulas have long intrigued cardiologists, in part because they are uncommon but also because of their physiologic effects, both local and general. For instance, a fistula in an extremity in children enhances growth of that extremity, whereas a fistula located in the kidney can cause systemic hypertension. Besides local effects, systemic arteriovenous fistulas, if large, have maj...
متن کاملHemodynamic and vascular responses to antihypertensive treatment with adrenergic blocking agents: a review.
P atients with established, uncomplicated arterial hypertension are characterized by a normal resting cardiac output and an increased systemic vascular resistance affecting the renal vascular bed most prominently.l-3 The elevated blood pressure can, generally speaking, be lowered by reducing the cardiac output, fower-ing the systemic vascular resistance, or through a combination of both. An ide...
متن کاملRedistribution of cardiac output caused by opening of arteriovenous anastomoses by a combination of azaperone and metomidate.
The effects of the butyrophenone, azaperone 5 mg kg-1 i.m. alone and after addition of the imidazole derivative metomidate 6 mg kg-1 i.v. were studied in eight conscious pigs. Fifteen minutes after administration of azaperone, systemic arterial pressure was reduced by 35% as a result of a 45% increase in systemic vascular conductance and 10% decrease in cardiac output (Q). After azaperone, 23% ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation. Cardiovascular interventions
دوره 9 8 شماره
صفحات -
تاریخ انتشار 2016